Cancer Metastasic Melanoma

The years 2011–16 represent a watershed era in melanoma history. This period has seen the approval of several molecularly targeted or immunotherapy drugs that meaningfully improve outcomes for patients with unresectable or metastatic melanoma. Targeting the MAP kinase (MAPK) pathway through combined BRAF and MEK inhibition has been very successful, yet the eventual development of resistance through reactivation of MAPK signalling is nearly inevitable. Paolo Ascierto and colleagues report the extended follow-up results of the coBRIM phase 3 trial evaluating the addition of the MEK inhibitor cobimetinib to the BRAF inhibitor vemurafenib in patients with previously untreated BRAF-mutant metastatic melanoma.

About Dra Martha Andrea Castro Médico WMA
I live in the Science Universe, Cycling World and Freedom Home, Mexico Brief biography: I am a Medical Doctor and General Surgeon. I specialize in difficult medical and clinical diagnostics. I subspecialize in Ischemic Cardiopathy. I am a Certified Medical Doctor by the World Medical Asociation. I have been practicing medical science for 28 years. In my private life I am a competitive amateur cyclist, animal lover, acoustic guitar player and song writer. My legs keep the wheels turning, my spirit keeps me going....AND MY BRAIN KEEPS ME BALANCED!

2 Responses to Cancer Metastasic Melanoma

  1. muppetalex1 says:

    Wow, looks like exciting times ahead for this. I can only hope that they are successful treatments. My father died of cancer, although it was asbestos related, but it is still a nasty way to go and anything that tackles cancer definitely gets my vote.



  2. muppetalex1 says:

    Hey Doc. Quick note on something that Islabikes are doing in the UK:

    They hand build childrens bikes. Anyway, their new idea is to retain ownership of the bike. Rent it to the child, or at least the parents and then, when the child outgrows the bike, they take the bike back, refurbish it and give it to another child. Wow. Sustainable recycleability. Awesome idea.



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